Targeting Viral cccDNA for Cure of Chronic Hepatitis B
نویسندگان
چکیده
منابع مشابه
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.
At least 250 million people worldwide are chronically infected with HBV, a small hepatotropic DNA virus that replicates through reverse transcription. Chronic infection greatly increases the risk for terminal liver disease. Current therapies rarely achieve a cure due to the refractory nature of an intracellular viral replication intermediate termed covalently closed circular (ccc) DNA. Upon inf...
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Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment can clear HBV but is limited by systemic side effects. We describe how interferon-α can induce specific degradation of the nuclear viral DNA without hepatotoxicity and propose lymphotoxin-β receptor activation as...
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ژورنال
عنوان ژورنال: Current Hepatology Reports
سال: 2020
ISSN: 2195-9595
DOI: 10.1007/s11901-020-00534-w